Known as the "Coca-Cola" route, the Marangu route is a classic trek on Mount Kilimanjaro. It is the oldest, most well-established route. Many favor the Marangu route because it is considered to be the easiest path on the mountain, given its gradual slope.
The Shira Route is a path that approaches Kilimanjaro from the west and is nearly identical to the Lemosho route. In fact, Shira was the original route and Lemosho is the improved variation.
The Machame route is considered a difficult route, and is better suited for more adventurous folks and those with some hiking or backpacking experience.